Uterine Histone Secretion Likely Fosters Early Embryo Development So Efforts to Mitigate Histone Cytotoxicity Should Be Cautious

The possible benefits of mitigating extracellular histone cytotoxicity have been outlined for the reproductive tract and other organs (e.g., Simon et al., 2013; Galuska et al., 2017; Lefrançais and Looney, 2017; Wygrecka et al., 2017; Yang et al., 2017). However, a reassessment of previously published data supports the notion that uterine histone secretion fosters early embryo development in multiple ways. (See below.) Hence, efforts to neutralize extracellular histone action in reproductive organs should be cautious. Thus far, there appears to be little discussion of how to preserve desirable histone effects while mitigating pathology caused by excessive extracellular histone actions.